Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice
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منابع مشابه
Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice
Using lymphocyte function-associated antigen (LFA)-1(-/-) mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs. Second, the alpha4 integrins, alpha4beta7 and alpha4beta1, have a hitherto unrecognized ability to compensate for the lack of LFA-1 ...
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To examine the role of lymphocyte function-associated antigen 1 (LFA-1) expression on murine B cells as it pertains to their function in T cell activation, we carried out antigen-presentation assays in tissue culture wells coated with a purified, secreted form of the murine intercellular adhesion molecule 1 (ICAM-1). We observed a significant decrease in the concentration of antigen required to...
متن کاملPrimary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein
We have isolated the cDNA for human lymphocyte function-associated antigen 3 (LFA-3), the ligand of the T lymphocyte CD2 molecule. The identity of the clones was established by comparison of the deduced amino acid sequence to the LFA-3 NH2-terminal and tryptic peptide sequences. The cDNA defines a mature protein of 222 amino acids that structurally resembles typical membrane-anchored proteins. ...
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Shedding of adhesion molecules has been described for members of the selectin and immunoglobulin superfamilies, but integrins are not known to be shed. Here, we describe shedding of the integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) from human leukocytes during the cutaneous inflammatory response to the blistering agent cantharidin. Expression of LFA-1 was significantly d...
متن کاملShedding of Lymphocyte Function-associated Antigen (LFA)-1 in a Human Inflammatory Response
word count: 196, Total text: < 5000. Corresponding author: Professor Dorian O. Haskard, BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K. Tel: +44 (0)20 83833064 Fax: +44 (0)20 83833064 [email protected] Blood First Edition Paper, prepublished online January 17, 2006; DOI 10.1182/blood-2005-09-3695 Cop...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1999
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.189.9.1467